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World J Stem Cells. Apr 26, 2014; 6(2): 120-133
Published online Apr 26, 2014. doi: 10.4252/wjsc.v6.i2.120
Published online Apr 26, 2014. doi: 10.4252/wjsc.v6.i2.120
Source of MSC | Main pathological features improved/repaired | Limitations/recommendations/conclusions | Ref. |
Human | Stem cells migrated to injured areas, functional recovery | hUCB may be a viable source of stem cells for treatment of neurological disorders | Saporta et al[69], 2003 |
Axonal regeneration, functional recovery | HUCBs and BDNF reduced the neurological function deficit to a moderate degree for SCI rats | Kuh et al[70], 2005 | |
Stem cells secrete neurotrophic hormones and remyelinating proteins, axonal remyelination | Studies on long-term survival of hUCBSC and remyelination are recommended. | Dasari et al[71], 2007 | |
Repair and maintenance of structural integrity of the injured spinal cord, downregulation of apoptosis, functional recovery | Role of hUCBSC in maintaining structural integrity and thereby promoting the long-term survival of neurons and oligodendrocytes in the injured spinal cord | Dasari et al[72], 2008 | |
Downregulation of neuronal apoptosis | Modulation of the micro environment of the injured spinal cord by application of hUCBSC might be a potential therapeutic modality | Dasari et al[75], 2009 | |
Downregulation of elevated tPA activity/expression in SCI rats | tPA is involved in secondary pathogenesis following spinal cord injury | Veeravalli et al[76] 2009 | |
Upregulation of MMP2, reduction of glial scar | hUCBSC treatment after SCI upregulates MMP-2 levels and reduces the formation of the glial scar | Veeravalli et al[77], 2009 | |
GDNF and VEGF were secreted in the injured spinal cord after transplantation of CD34+ cells | CD34+ cell therapy may be beneficial in reversing the SCI-induced spinal cord infarction and apoptosis and hindlimb dysfunction | Kao et al[78], 2008 | |
Serum IL-10 levels increased, TNF-α levels decreased, functional recovery | Recovery of SCI-induced hind limb dysfunction is by increasing serum levels of IL-10, VEGF and GDNF in SCI rats. | Chen et al[79] 2008 | |
Infarct size and blood vessel density at the injured site were significantly different in the treated group, functional recovery | Transplantation of CD34(+) HUCBCs during acute phase could promote functional recovery better than during subacute phase after SCI by raising blood vessel density | Ning et al[80], 2013 |
- Citation: Dasari VR, Veeravalli KK, Dinh DH. Mesenchymal stem cells in the treatment of spinal cord injuries: A review. World J Stem Cells 2014; 6(2): 120-133
- URL: https://www.wjgnet.com/1948-0210/full/v6/i2/120.htm
- DOI: https://dx.doi.org/10.4252/wjsc.v6.i2.120