Neural stem cells isolated from amyloid precursor protein-mutated mice for drug discovery

Figure 1 Transgenic protein expression and population doubling. Micrograph shows the positive 6E10 staining of Tg2576 plated cells derived from secondary neurospheres (A) and the related negative staining of wild type derived cells (B). A decrease in population doubling seems to occur in the first few days of primary neurosphere development (C), and is not repeated in secondary neurosphere formation (D). Statistical analysis: Student’s t-test. Graphs represent mean ± SE and asterisks represent significant differences between Tg2576 and Wt at the same DIV (^aP < 0.05).