Epigenetics and chromatin plasticity in embryonic stem cells

Figure 2 Morphology of colonies of mouse embryonic stem cells (line D3). A-D: The splicing factor stem cells (SC)-35 (red) was visualized in the cell nuclei (blue) within mouse embryonic stem cells (mESC) colonies in pluripotent cells and after retinoic acid (RA)-induced cell differentiation; E, F: Cell nuclei (blue) that were positive for heterochromatin protein 1 (HP1)β (red) were mapped within a pluripotent mESC colony and after RA-induced differentiation; G-J: Pattern of polycomb group protein BMI1 (red) in pluripotent and RA-differentiated ESCs (blue). Individual nuclei in frames G, I were magnified in panels H and J.