Umbilical cord blood mesenchymal stem cells protect amyloid-β42 neurotoxicity via paracrine

Figure 4 Paracrine action of human umbilical cord blood-derived mesenchymal stem cells in amyloid-β42 neurotoxicity in vitro. We previously reported that human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) secrete soluble intercellular adhesion molecule-1 (sICAM-1) and galectin-3 for Aβ clearance and neuron survival, respectively. We also showed anti-apoptotic role of decorin and progranulin in amyloid-β42-neurotoxicity in vitro. Recently, MSCs have become regarded as drugable cells because they secrete various beneficial proteins for healing of damaged sites.