Editorial
Copyright ©2011 Baishideng Publishing Group Co.
World J Stem Cells. Jan 26, 2011; 3(1): 1-8
Published online Jan 26, 2011. doi: 10.4252/wjsc.v3.i1.1
Figure 1
Figure 1 Immune modulation effects of mesenchymal stromal cells on various cells of the immune system. Several soluble factors have been identified to play a major role in immunosuppressive effects of mesenchymal stromal cells (MSC) including prostaglandin E2 (PGE2), transforming growth factor (TGF-β), hepatocyte growth factor (HGF), indoleamine 2,3-dioxygenase (IDO), interleukin-10 (IL-10), nitric oxide, IL-6 and HLA-G. Moreover, cytokines (e.g. IFN-γ), chemokines and Toll-like receptors (TLR) ligands have been shown to modulate/activate immune suppression by MSC.