Mesenchymal stem cells: Molecular characteristics and clinical applications

doi:10.4252/wjsc.v2.i4.67

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Aug 26, 2010 (publication date) through Jan 31, 2025

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Aug 26, 2010; 2(4): 67-80
Published online Aug 26, 2010. doi: 10.4252/wjsc.v2.i4.67

Table 1 Examples of in vivo applications of mesenchymal stem cells

Animal	Disease model	Outcome
Baboon	Skin graft transplantation	Prolonged skin graft survival[169]
Mouse	GvHD	Prevention of GvHD[124,170]
	EAE	Prevention of EAE development and improved functional recovery[129,171]
	CIA	Improved arthritic symptoms[172]
	NOD	Prevent T-cell mediated beta-cell destruction[173]
	SLE	Improved symptoms, serological markers and renal function[137]
	Lung injury	Decreased severity of endotoxin induced lung injury and improved survival[174]
Rat	Glomerulonephritis	Accelerate glomerular healing[175]
	Critical size defect	Improved healing and function[176]
	Experimental colitis	Improved survival and healing[177]
	Dilated rat cardiomyopathy	Improved cardiac function[178]
	Heart transplantation	Participate in tissue repair by giving rise to myofibroblasts and cardiomyocytes[179]
	Myocardial infarction	Improved cardiac function and survival[143]
	Cerebral ischemia	Reduced gross lesion volume and improved functional recovery[151]

CIA: Collagen induced arthritis; EAE: Experimental autoimmune encephalomyelitis; GvHD: Graft-versus-Host-Disease; NOD: Non-obese diabetic; SLE: Systemic lupus erythematosus.

Citation: Rastegar F, Shenaq D, Huang J, Zhang W, Zhang BQ, He BC, Chen L, Zuo GW, Luo Q, Shi Q, Wagner ER, Huang E, Gao Y, Gao JL, Kim SH, Zhou JZ, Bi Y, Su Y, Zhu G, Luo J, Luo X, Qin J, Reid RR, Luu HH, Haydon RC, Deng ZL, He TC. Mesenchymal stem cells: Molecular characteristics and clinical applications. World J Stem Cells 2010; 2(4): 67-80
URL: https://www.wjgnet.com/1948-0210/full/v2/i4/67.htm
DOI: https://dx.doi.org/10.4252/wjsc.v2.i4.67