Non-coding RNAs in adipose-derived stem cell exosomes: Mechanisms, therapeutic potential, and challenges in wound healing

Figure 3 Mechanisms by which long non-coding RNAs from adipose-derived stem cell exosomes promote wound healing. # represents pretreated with hypoxia. miRNAs: MicroRNAs; cirRNAs: Circular RNAs; lncRNAs: Long non-coding RNAs; EGR-1: Early growth response factor-1; MALAT1: Metastasis-associated lung adenocarcinoma transcript 1; NORAD: Non-coding RNA activated by DNA damage; FOXD2-AS1: FOXD2 antisense RNA 1; DKC1: Dyskeratosis Congenita 1; PAQR3: Progestin and adipoQ receptor family member 3; TLR7: Toll-like receptor 7; VEGF: Vascular endothelial growth factor; PPAR: Peroxisome proliferator-activated receptor; STAT3: Signal transducer and activator of transcription 3; DDR2: Discoidin domain receptor tyrosine kinase 2; FGF2: Fibroblast growth factor 2; ROCK2: Rho-associated coiled-coil containing protein kinase 2; Ulk1: Unc-51 like autophagy activating kinase 1; ROS: Reactive oxygen species; TNF-α: Tumor necrosis factor-alpha; IL: Interleukin.