Non-coding RNAs in adipose-derived stem cell exosomes: Mechanisms, therapeutic potential, and challenges in wound healing

Figure 2 Mechanisms by which microRNAs from adipose-derived stem cell exosomes promote wound healing. miRNAs: MicroRNAs; cirRNAs: Circular RNAs; lncRNAs: Long non-coding RNAs; JAZF1: Juxtaposed with another zinc finger protein 1; PTEN: Phosphatase and tensin homolog deleted on chromosome ten; PIK3R2: Phosphoinositide-3-kinase regulatory subunit 2; DLL-4: Delta-like ligand-4; VEGF: Vascular endothelial growth factor; PI3K: Phosphoinositide-3-kinase; Akt: Protein kinase B; SERPINH1: Serine peptidase inhibitor 1; p-ERK2: Phosphorylated extracellular signal-regulated kinase 2; TMEM127: Transmembrane protein 127; NF-κB: Nuclear factor-kappaB; TGFBR3: Transforming growth factor-beta type III receptor; TGF-β: Transforming growth factor beta; E2F1: Transcription factor 1; TNF-α: Tumor necrosis factor-alpha; IL: Interleukin; α-SMA: Alpha-smooth muscle actin; COL-1: Collagen I; FN: Fibronectin; MMP-9: Matrix metalloproteinase-9.