Evaluating the efficacy of stem cells in treating severe dry eye disease

Table 3 Registered clinical trials for mesenchymal stem cells in dry eye disease from the ClinicalTrials.gov database (July 31, 2024)

No.	Study	Diagnosis	Drug	Intervention	Patient number	Location(s)	Trial reference number (NCT)
1	Effect of UMSCs derived exosomes on dry eye in patients with cGVHD	Dry eye	UMSC-Exo	Transconjunctival injection	27	Guangzhou, Guangdong, China	04213248
2	Mesenchymal stem cell therapy of dry eye disease in patients with Sjögren’s syndrome	Keratoconjunctivitis sicca, in Sjögren’s syndrome	AD-MSCs	Transconjunctival injection	40	Copenhagen, DK, Denmark	04615455
3	Safety and efficacy of pluripotent stem cell-derived mesenchymal stem cell exosome (PSC-MSC-Exo) Eye drops treatment for dry eye disease post refractive surgery and associated with blepharospasm	Dry eye post refractive surgery	PSC-MSC-Exo	Topical eye drops	12	Hangzhou, Zhejiang, China	05738629
4	Treatment with allogeneic adipose-derived mesenchymal stem cells in patients with aqueous deficient dry eye disease	Aqueous deficiency dry eye disease, keratoconjunctivitis sicca	AD-MSCs	Lacrimal gland injection	7	Copenhagen, DK, Denmark	03878628
5	Allogeneic mesenchymal stem cells transplantation for primary Sjögren’s syndrome (pSS)	Keratoconjunctivitis sicca, in Sjögren’s syndrome	AlloMSC	Intravenous infusion (single dose)	20	Nanjing, Jiangsu, China	00953485
6	Therapeutic effect of stem cell eye drops on dry eye disease	Dry eye syndromes	MSC eye drops	Topical eye drops	10	Nanjing, Jiangsu, China	05784519

UMSC-Exo: Umbilical cord-derived mesenchymal stem cell exosome; AD-MSCs: Adipose-derived mesenchymal stem cells; PSC-MSC-Exo: Pluripotent stem cell-derived mesenchymal stem cell exosome; AlloMSC: Allogeneic mesenchymal stem cell; MSC: Mesenchymal stem cell; cGVHD: Chronic graft-vs-host disease; pSS: Primary Sjögren’s syndrome; UMSC: Umbilical cord-derived mesenchymal stem cell.