Exosomal miR-137-3p targets UBE3C to activate STAT3, promoting migration and differentiation into endometrial epithelial cell of human umbilical cord mesenchymal stem cells under hypoxia

Figure 7 Under hypoxic injury, endometrial epithelial cells secrete exosomes rich in miR-137-3P, which act on umbilical cord blood mesenchymal stem cells. Through the sponge adsorption effect, miR-137-3P in these exosomes adsorbs ubiquitin protein ligase E3C, thereby promoting the phosphorylation of mitogen-activated protein kinase/protein kinase B. It also promotes the signal transducer and activator of transcription 3-mediated epithelial markers CD9/CD13, which in turn promotes the differentiation of umbilical cord blood mesenchymal stem cells into endometrial epithelial cells. HucMSC: Human umbilical cord mesenchymal stem cell; UBE3C: Ubiquitin protein ligase E3C; STAT3: Signal transducer and activator of transcription 3; MAPK: Mitogen-activated protein kinase; AKT: Protein kinase B.