Exosomal miR-137-3p targets UBE3C to activate STAT3, promoting migration and differentiation into endometrial epithelial cell of human umbilical cord mesenchymal stem cells under hypoxia

Figure 5 miR-137-3p facilitated signal transducer and activator of transcription 3 activation through targeting ubiquitin protein ligase E3C. A: The potential interaction between miR-137-3p and ubiquitin protein ligase E3C (UBE3C), as predicted by miRDB; B: The comparative luciferase activities; C: Human umbilical cord mesenchymal stem cell were transfected with miR-137-3p mimic, and the mRNA expressions of UBE3C were quantified; D: Western blot analysis to ascertain the protein levels of UBE3C and signal transducer and activator of transcription 3. ^aP < 0.001 vs negative control mimic group, ^bP < 0.01 vs negative control mimic group, n = 3. Results are presented as mean ± SD. UBE3C: Ubiquitin protein ligase E3C; NC: Negative control; UTR: Untranslated region.