Mesenchymal stem cell exosomes enhance the development of hair follicle to ameliorate androgenetic alopecia

Figure 4 Human adipose-derived mesenchymal stem cell exosomes improve the hair regeneration in androgenetic alopecia mice model. A: Schematic flowchart of the experiment of testosterone propionate-treated and shaved in androgenetic alopecia mouse model; B: PKH26-labeled human adipose-derived mesenchymal stem cell exosome (red) retention in the site of hair follicle; C: Hair growth of C57BL/6 mice in each group; D: hematoxylin and eosin staining of mouse skin histopathological sections in each group; E: Hair growth score in each group; F: The number of follicles in each group. Differences among four groups were assessed by Tukey’s multiple comparison test and one-way ANOVA; error bars represent SEM. ^bP < 0.01, compared with testosterone propionate-treated group. Six mice were randomly selected from each group for histological examination. TP: Testosterone propionate; hADSC-Exo: Human adipose-derived mesenchymal stem cell exosome.