MiR-21-5p-enriched exosomes from hiPSC-derived cardiomyocytes exhibit superior cardiac repair efficacy compared to hiPSC-derived exosomes in a murine MI model

Figure 7 Data analysis of sequencing microRNA. A: Enrichment result of biological processes (BP) is Gene Ontology (GO): 0050794 regulation of cellular processes; GO: 0051171 regulation of nitrogen compound metabolic process; GO: 0051173 positive regulation of nitrogen compound metabolic process; B: Enrichment results of cellular components (CC) are GO: 0005737 cytoplasm, GO: 0043227 membrane bound organelle, GO: 0043231 intracellular membrane bound organelle; C: Molecular function (MF) enrichment results are GO: 0005515 protein binding, GO: 0003824 catalytic activity, and GO: 0046872 metal ion binding; D: Four miRNAs hsa-miR-148a-3p, hsa-miR-21-5p, hsa-miR-151a-3p and hsa-miR-26a-5p, were obtained from the collection of highly expressed microRNAs in human-induced pluripotent stem cell (hiPSC)-cardiomyocyte (CM)-exosome (exo) and iPSC exo; E: MicroRNA expression in AC16, hiPSC-exo, hiPSC-CM-exo, ^bP < 0.01 comparison with AC16-exo, ^cP < 0.05 comparison with hiPSC-exo, ^dP < 0.01 comparison with hiPSC-exo.