MiR-21-5p-enriched exosomes from hiPSC-derived cardiomyocytes exhibit superior cardiac repair efficacy compared to hiPSC-derived exosomes in a murine MI model

Figure 5 Human-induced pluripotent stem cell-derived cardiomyocyte exosomes reduce apoptosis when administered to infarcted rat hearts. A: Apoptotic cells were identified in sections from the border zone of infarcted hearts from animals across various groups using the transferase dUTP nick-end labeling assay; B: Apoptosis was quantified as the percentage of cells positive for transferase dUTP nick-end labeling staining. Data are shown as the mean ± SD from n = 3 biologically independent samples among different groups. ^aP < 0.05, ^bP < 0.01. hiPSC-CMs: Human-induced pluripotent stem cell-derived cardiomyocytes; hiPSC-CM-exos: Human-induced pluripotent stem cell-derived cardiomyocyte-derived exosomes; iPSCs: Induced pluripotent stem cells; iPSC-CMs: Induced pluripotent stem cell-derived cardiomyocytes; iPSC-exos: Induced pluripotent stem cell-derived exosomes; PBS: Phosphate-buffered saline; TUNEL: Transferase dUTP nick-end labeling.