MiR-21-5p-enriched exosomes from hiPSC-derived cardiomyocytes exhibit superior cardiac repair efficacy compared to hiPSC-derived exosomes in a murine MI model

Figure 4 Human-induced pluripotent stem cell-derived cardiomyocytes exosomes reduce myocardial fibrosis. A: Representative images of Masson trichrome staining from various groups are presented in the upper panel, with a high magnification view shown in the lower panel (100 ×); B and C: The Masson average optical density per area was used as an indicator of the cardiac fibrosis level. Data are shown as the mean ± SD from n = 4 biologically independent samples across different groups. ^aP < 0.05; ^bP < 0.01. hiPSC-CMs: Human-induced pluripotent stem cell-derived cardiomyocytes; hiPSC-CM-exos: Human-induced pluripotent stem cell-derived cardiomyocyte-derived exosomes; iPSCs: Induced pluripotent stem cells; iPSC-CMs: Induced pluripotent stem cell-derived cardiomyocytes; iPSC-exos: Induced pluripotent stem cell-derived exosomes; LV: Left ventricular; PBS: Phosphate-buffered saline.