MiR-21-5p-enriched exosomes from hiPSC-derived cardiomyocytes exhibit superior cardiac repair efficacy compared to hiPSC-derived exosomes in a murine MI model

Figure 3 Human-induced pluripotent stem cell-derived cardiomyocyte exosomes reduce infarction area. A: Representative images of 2,3,5-triphenyltetrazoliumchloride staining across five continuous slices of the left ventricle from various group hearts; B: The infarct size, which is expressed as a percentage of the total left ventricle area, is depicted. Data are shown as the mean ± SD from n = 3 biologically independent samples among different groups. ^aP < 0.05. hiPSC-CMs: Human-induced pluripotent stem cell-derived cardiomyocytes; hiPSC-CM-exos: Human-induced pluripotent stem cell-derived cardiomyocyte-derived exosomes; iPSCs: Induced pluripotent stem cells; iPSC-CMs: Induced pluripotent stem cell-derived cardiomyocytes; iPSC-exos: Induced pluripotent stem cell-derived exosomes; LV: Left ventricular; PBS: Phosphate-buffered saline.