Fetal mice dermal mesenchymal stem cells promote wound healing by inducing M2 type macrophage polarization

Figure 4 Evaluation of wound healing and tissue analysis in mice following thoracoscopic surgery. A: Mice were euthanized on postoperative days 0, 7, and 14; wound healing was photographed and documented; B: Analysis of wound healing rate; C and D: Hematoxylin and eosin and Masson’s trichrome staining of traumatized skin on day 14 (× 40 magnification); E: The area of blue-stained collagen in Masson’s trichrome-stained sections was quantified using ImageJ software and statistically analyzed; F: Mouse trauma tissue extracted on day 14 for quantitative reverse transcriptase polymerase chain reaction analysis to detect arginase-1 expression. ^bP < 0.01. HE: Hematoxylin and eosin; Arg-1: Arginase-1; FDMSC: Fetal dermal mesenchymal stem cell.