Effect of tandem autologous stem cell transplantation on survival in pediatric patients with high-risk solid tumors in South China

Table 2 Univariable analysis of 35 pediatric patients with high-risk neuroblastoma, n (%)

Characteristics	Total (n = 35)	3-year OS			3-year EFS
		mean ± SD	χ2	P value	mean ± SD	χ2	P value
Age
< 36 months	10 (28.6)	100			100
≥ 36 months	25 (71.4)	55.4 ± 12.2	4.85	0.03a	51.3 ± 12.0	4.85	0.03a
Sex
Male	26 (74.3)	71.8 ± 10.5			67.9 ± 10.7
Female	9 (25.7)	57.1 ± 18.7	0.37	0.54	57.1 ± 18.7	1.7	0.36
LDH
< 1000 U/L	25 (71.4)	82.0 ± 8.1			77.4 ± 8.9
≥ 1000 U/L	10 (28.6)	30.0 ± 22.6	4.32	0.04a	30.0 ± 22.6	3.15	0.08
MYCN
Non-amplified	23 (65.7)	62.4 ± 14.0			57.9 ± 13.7
Amplified	5 (14.3)	100			100
Unknown	7 (20.0)	57.1 ± 18.7	2.72	0.10	57.1 ± 18.7	2.43	0.12
NSE
< 200 ng/mL	10 (28.6)	70.0 ± 14.5			70.0 ± 14.5
≥ 200 ng/mL	21 (60.0)	68.8 ± 14.8			63.7 ± 14.5
Unknown	4 (11.4)	50.0 ± 25.0	0.12	0.73	50.0 ± 25.0	0.19	0.66

^aP < 0.05.

OS: Overall survival; EFS: Event-free survival; LDH: Lactate dehydrogenase; NSE: Neuron-specific enolase.