Immortalization of epidural fat-derived mesenchymal stem cells: In vitro characterization and adipocyte differentiation potential

Figure 4 Results of proteomics analysis of isolated epidural fat-derived mesenchymal stem cells. Immortalized cells exhibited significantly altered protein expression patterns and an increased expression of components involved in cell proliferation pathways. A: Heatmap results of the isolated epidural fat-derived mesenchymal stem cells (EF-MSCs); B: Kyoto Encyclopedia of Genes and Genomes pathway enrichment graph for isolated EF-MSCs, indicating increased DNA replication in immortalized cells; C and D: Protein expression patterns visualized through principal component analysis and Venn diagram plots. hTERT: Human telomerase reverse transcriptase.