Microvesicles derived from mesenchymal stem cells inhibit acute respiratory distress syndrome-related pulmonary fibrosis in mouse partly through hepatocyte growth factor

Figure 5 Western blot analysis of the effects of mesenchymal stromal cell-derived microvesicles on pulmonary fibrosis-related proteins in acute respiratory distress syndrome pulmonary fibrosis model mice. A: Western blot bands of fibrosis-related proteins in the lung tissues of each group; B: Relative expression of fibrosis-related proteins. ^aP < 0.05, vs the control group; ^bP < 0.05, vs the pulmonary fibrosis group; ^cP < 0.05, vs the mesenchymal stromal cell-derived microvesicles (MSC-MVs) group (n = 6). Control, acute respiratory distress syndrome (ARDS), pulmonary fibrosis, MSC, MSC-MVs and low hepatocyte growth factor (HGF)-MSC-MVs represent the control group, ARDS group, pulmonary fibrosis group, MSC group, MSC-MVs group and low HGF-MSC-MVs group, respectively. α-SMA: α-smooth muscle actin; COL: Collagen.