Exosomes from umbilical cord mesenchymal stromal cells promote the collagen production of fibroblasts from pelvic organ prolapse

Figure 8 Characterization of microRNA profiles in human umbilical cord mesenchymal stromal cell-derived exosome and verification of beneficial targeted microRNAs. A: Venn diagram of the top 27 shared microRNAs (miRNAs) in human umbilical cord mesenchymal stromal cell-derived exosome (hucMSC-Exo) (n = 3); B: Pie charts showing the abundances of different miRNAs in hucMSC-Exo; C: The regulatory network depicting the predicted miRNAs of the gene of interest matrix metalloproteinase 11 (MMP11) in the top 27 list and the enrichment terms of these miRNAs in the Gene Ontology analysis; D: Quantitative real-time polymerase chain reaction was performed to evaluate the mRNA levels of MMP11. ^bP < 0.01. MMP: Matrix metalloproteinase; FBS: Fetal bovine serum; Exo: Exosome.