Exosomes from umbilical cord mesenchymal stromal cells promote the collagen production of fibroblasts from pelvic organ prolapse

Figure 2 Differences in human vaginal collagen deposition between patients with and without pelvic organ prolapse. Disordered collagen fibers in the pelvic organ prolapse vaginal wall. A: Masson’s trichrome staining images of vaginal tissues; B: Images of vaginal tissues stained with Sirius Red were collected by brightfield microscopy; C and D: Quantification of the collagen content in A and B; E: Sirius Red-stained tissues were scanned via polarized light microscopy; F: Representative immunohistochemistry images showing the distribution of Col1 in the human vaginal wall; G: Immunofluorescence showing the expression of Col1 and vimentin (a fibroblast marker) in the human vaginal wall. ^cP < 0.001; ^dP < 0.0001. POP: Pelvic organ prolapse.