Outcomes of combined mitochondria and mesenchymal stem cells-derived exosome therapy in rat acute respiratory distress syndrome and sepsis

Figure 7 Protein expressions of mitochondrial damaged markers and cellular junctions by day 5 after acute respiratory distress syndrome induction. A: Protein expression of dynamin- related protein 1, control vs other groups with different letters, ^aP < 0.0001, ^bP < 0.05, ^cP < 0.01; B: Protein expression of p22phox, control vs other groups with different letters, ^aP < 0.0001, ^bP < 0.05, ^cP < 0.01; C: Protein expression of cytosolic cytochrome C, control vs other groups with different letters, ^aP < 0.0001, ^bP < 0.05, ^cP < 0.01; D: Protein expression of zonula occludens-1, control vs other groups with different letters, ^aP < 0.0001, ^bP < 0.05, ^cP < 0.01; E: Protein expression of E-cadherin, control vs other groups with different letters, ^aP < 0.0001, ^bP < 0.05, ^cP < 0.01. All statistical analyses were performed by one-way ANOVA, followed by Bonferroni multiple comparison post hoc test (n = 6 for each group). Drp1: Dynamin-related protein 1; cyto-CytC: Cytosolic cytochrome C; ZO-1: Zonula occludens-1; SC: Sham-operated control; ARDS: Acute respiratory distress syndrome; SS: Sepsis syndrome; mito^Ex: Exogenous mitochondria; EX^AD: Adipose-derived mesenchymal stem cells-derived exosomes.