Patient-derived induced pluripotent stem cells with a MERTK mutation exhibit cell junction abnormalities and aberrant cellular differentiation potential

Figure 5 Transcriptomic and proteomic analyses indicating that human induced pluripotent stem cell-derived extracellular vesicles play a crucial role in regulating cell adhesion and differentiation. A: Differentially expressed mRNAs between patient human induced pluripotent stem cell (iPSC)-derived extracellular vesicles (EVs) and control iPSC-derived EVs; B: Gene Ontology (GO)-cellular component enrichment analysis of differentially expressed mRNAs; C: Differentially expressed microRNA between patient iPSC-derived EVs and control iPSC-derived EVs; D: GO-cellular component enrichment analysis of differentially expressed microRNA target genes; E: Abundance of proteins from patient iPSC-derived EVs and control iPSC-derived EVs. The abscissa represents the protein number, and the ordinate represents the normalized protein expression score. The top 10 and bottom 10 expressed proteins are displayed; F: Differentially expressed proteins between patient iPSC-derived EVs and control iPSC-derived EVs; G-I: GO enrichment analysis for differentially expressed proteins; J and K: Kyoto Encyclopedia of Genes and Genomes and Reactome enrichment analyses for differentially expressed proteins; L: Gene set enrichment analysis of patient iPSC-derived EVs and control iPSC-derived EVs. GO: Gene Ontology; KEGG: Kyoto Encyclopedia of Genes and Genomes; BP: Biological progress; CC: Cellular component; MF: Molecular function.