Gossypol acetic acid regulates leukemia stem cells by degrading LRPPRC via inhibiting IL-6/JAK1/STAT3 signaling or resulting mitochondrial dysfunction

Figure 6 Gossypol acetic acid inhibits leukemia stem cells partially via inhibiting interleukin 6/janus kinase 1/signal transducer and activator of transcription 3 signaling. A and B: After being treated with gossypol acetic acid (GAA) or treated with S3I-210 for 24 h, cell viability was performing by employing CCK-8 assay (A), and colony formation ability was measured (B). ^aP < 0.05, vs GAA/S3I-201(-) group; ^bP < 0.05, vs GAA (+) group. GAA: Gossypol acetic acid.