Gossypol acetic acid regulates leukemia stem cells by degrading LRPPRC via inhibiting IL-6/JAK1/STAT3 signaling or resulting mitochondrial dysfunction

Figure 4 Gossypol acetic acid induced chemosensitivity via degrading leucine-rich pentatricopeptide repeat-containing protein. A: After being transfected with leucine-rich pentatricopeptide repeat-containing protein-coding plasmid, overexpression efficiency was measured by performing western blot. ^aP < 0.05, vs vector group; B: After being pre-treated with gossypol acetic acid (GAA), KG1a-SCs or Kasumi-1-SCs were treated with cytarabine for extra 24 h and cell viability was measured. ^aP < 0.05, mock/GAA group. LRPPRC: Leucine-rich pentatricopeptide repeat-containing protein; GAA: Gossypol acetic acid.