Long-term outcome of stem cell transplantation with and without anti-tumor necrotic factor therapy in perianal fistula with Crohn’s disease

Table 3 Patient characteristics and clinical variables between closure and non-closure groups, n (%)

	No closure (n = 15)	Closure (n = 50)	P value
Age, median (IQR) (yr)	28.0 (23.0-33.0)	26.0 (20.8-31.0)	0.433
Sex			0.316
Male	5 (33.3)	24 (48.0)
Female	10 (66.7)	26 (52.0)
Montreal classification
Age at onset			0.227
A1 (≤ 16 yr)	1 (6.7)	10 (20.0)
A2 (17-40 yr)	14 (93.3)	40 (80.0)
A3 (≥ 41 yr)	0 (0.0)	0 (0.0)
Location			0.285
L1 (Ileum)	4 (26.7)	8 (16.0)
L2 (Colon)	0 (0.0)	6 (12.0)
L3 (Ileocolon)	11 (73.3)	36 (72.0)
Behavior			0.998
B1 (non-stricturing, non-penetrating)	10 (66.7)	33 (66.0)
B2 (stricturing)	3 (20.0)	10 (20.0)
B3 (penetrating)	2 (13.3)	7 (14.0)
Fistula type			0.572
Simple	3 (20.0)	7 (14.0)
Complex	12 (80.0)	43 (86.0)
Multiple fistula	8 (53.3)	14 (28.0)	0.069
Fistula length > 7 cm	6 (40.0)	7 (14.0)	0.027
CDAI, mean ± SD	98.84 ± 54.62	87.01 ± 51.16	0.444
Proctitis	10 (66.7)	15 (30.0)	0.002
Stricture	4 (26.7)	2 (8.0)	0.008
Abscess	2 (13.3)	3 (6.0)	0.350
Recto-vaginal fistula	1 (6.7)	4 (8.0)	0.865
Medical treatment
Immunomodulators	8 (53.3)	31 (62.0)	0.548
Biologics	9 (60.0)	18 (36.0)	0.098
Smoking	0 (0.0)	2 (4.0)	0.733
Previous fistula OP	15 (100.0)	33 (100.0)	1.000
No. previous fistula OP, mean ± SD (times)	4.27 ± 5.06	2.36 ± 1.91	0.173
Disease duration, mean ± SD (yr)	5.53 ± 4.24	6.66 ± 5.29	0.454
Follow-up, mean ± SD (months)	63.87 ± 40.12	66.48 ± 30.52	0.788

IQR: Interquartile range; CDAI: Crohn’s Disease Activity Index; OP: Operation.