Therapeutic utility of human umbilical cord-derived mesenchymal stem cells-based approaches in pulmonary diseases: Recent advancements and prospects

doi:10.4252/wjsc.v16.i2.70

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Feb 26, 2024 (publication date) through Feb 21, 2025

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Feb 26, 2024; 16(2): 70-88
Published online Feb 26, 2024. doi: 10.4252/wjsc.v16.i2.70

Table 5 Clinical trials of umbilical cord mesenchymal stem cells therapy for patients with pulmonary fibrosis

No	Trial ID	UC-MSCs administration protocol			Phase	Status	Patients	Age (yr)	Follow-up time	Mask	Allocation	Country
No	Trial ID	Frequency	Dose (cells)	Route	Phase	Status	Patients	Age (yr)	Follow-up time	Mask	Allocation	Country
1	NCT05468502	1	Dose A: 6.0 × 10⁶, dose B: 3.0 × 10⁷, dose C: 6.0 × 10⁷, dose D: 9.0 × 10⁷	IV	I	Recruiting	18	50-75	N/A	Open-label	N/A	China
2	NCT02277145	1	1 × 10⁶/kg	IV	I	Completed	10	Adult, older adult	N/A	Open-label	N/A	China
3	NCT05016817	1	1 × 10⁸	IV	I	Recruiting	20	Child, adult, older adult	48 months	Open-label	N/A	Antigua and Barbuda, Argentina, Mexico

UC-MSCs: Umbilical cord mesenchymal stem cells; IV: Intravenous; N/A: Not available.

Citation: Meng M, Zhang WW, Chen SF, Wang DR, Zhou CH. Therapeutic utility of human umbilical cord-derived mesenchymal stem cells-based approaches in pulmonary diseases: Recent advancements and prospects. World J Stem Cells 2024; 16(2): 70-88
URL: https://www.wjgnet.com/1948-0210/full/v16/i2/70.htm
DOI: https://dx.doi.org/10.4252/wjsc.v16.i2.70