Therapeutic utility of human umbilical cord-derived mesenchymal stem cells-based approaches in pulmonary diseases: Recent advancements and prospects

Table 3 Clinical trials of umbilical cord mesenchymal stem cells therapy for patients with bronchopulmonary dysplasia

No	Trial ID	UC-MSCs administration protocol			Phase	Status	Patients	Age	Follow-up time	Mask	Allocation	Country
		Frequency	Dose (cells)	Route
1	NCT04062136	2 (at days 1 and 8)	1 × 106/kg	IV	I	Unknown	10	1-6 months	N/A	Open-label	N/A	Vietnam
2	NCT02381366	1	Dose A: 1 × 107/kg; dose B: 2 × 107/kg	N/A	I/II	Completed	12	3-14 d	N/A	Open-label	N/A	United States
3	NCT03645525	1	2 × 107/kg	Endobronchial	I/II	Recruiting	180	2-3 wk	N/A	Quadruple-blind	Randomized	China
4	NCT03601416	1	Dose A: 1 × 106/kg, dose B: 5 × 106/kg	IV	II	Unknown	21	28 d to 1 yr	N/A	Open-label	Randomized	China
5	NCT03558334	1	Dose A: 1 × 106/kg, dose B: 5 × 106/kg	IV	I	Unknown	12	28 d and older	N/A	Open-label	Non-randomized	China
6	NCT01207869	1	3 × 106/kg	Endobronchial	I	Unknown	10	1 wk to 6 months	N/A	Double-blind	Randomized	China
7	NCT03873506	1	Dose A: 1 × 106/kg, dose B: 5 × 106/kg	IV	I	Unknown	30	1 months to 5 yr	N/A	Open-label	N/A	China
8	NCT03774537	1	Dose A: 1 × 106/kg, dose B: 5 × 106/kg	IV	I/II	Unknown	20	4-14 d	N/A	Open-label	Non-randomized	China
9	NCT03631420	1	Dose A: 3 × 106/kg, dose B: 1 × 107/kg, dose C: 3 × 107/kg	N/A	I	Recruiting	9	3-51 d	N/A	Open-label	N/A	China
10	NCT01632475	1	Dose A: 1 × 107/kg, dose B: 2 × 107/kg	IV	I	Active, not recruiting	9	4 months to 2 yr	N/A	Open-label	N/A	Korea
11	NCT01297205	1	Dose A: 1 × 107/kg, dose B: 2 × 107/kg	IV	I	Completed	9	5-14 d	N/A	Open-label	N/A	Korea
12	NCT04003857	1	1 × 107/kg	IV	II	Recruiting	60	6-60 months	N/A	Triple-blind	Randomized	Korea
13	NCT01897987	1	1 × 107/kg	IV	N/A	Completed	62	7 months	60 months	Triple-blind	Randomized	Korea
14	NCT01828957	1	1 × 107/kg	IV	II	Completed	69	5-14 d	N/A	Quadruple-blind	Randomized	Korea
15	NCT02023788	1	Dose A: 1 × 107/kg, dose B: 2 × 107/kg	IV	I	Completed	8	45-63 months	5 yr	Open-label	N/A	Korea
16	NCT03378063	1	N/A	N/A	I	Withdrawn	100	1-3 months	N/A	Open-label	Non-randomized	China
17	NCT03392467	1	N/A	N/A	II	Recruiting	60	Up to 13 d	N/A	Quadruple-blind	Randomized	Korea
18	NCT04255147	1	Dose A: 1 × 106/kg, dose B: 3 × 106/kg, dose C: 1 × 107/kg	IV	I	Recruiting	9	7-28 d	N/A	Open-label	N/A	Canada

UC-MSCs: Umbilical cord mesenchymal stem cells; IV: Intravenous; N/A: Not available.