VX-509 attenuates the stemness characteristics of colorectal cancer stem-like cells by regulating the epithelial-mesenchymal transition through Nodal/Smad2/3 signaling

doi:10.4252/wjsc.v16.i2.207

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World Journal of Stem Cells

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World J Stem Cells. Feb 26, 2024; 16(2): 207-227
Published online Feb 26, 2024. doi: 10.4252/wjsc.v16.i2.207

Table 1 Pathways related to cancer stem cells in Reactome and Gene Ontology databases

Stem cell function related pathways	Pathway ID	Gene count
GO: Somatic stem cell population maintenance	GO: 0035019	72
GO: Negative regulation of stem cell differentiation	GO: 2000737	20
GO: Stem cell proliferation	GO: 0072089	118
GO: Hematopoietic stem cell differentiation	GO: 0060218	79
GO: Negative regulation of stem cell proliferation	GO: 2000647	16
GO: Stem cell division	GO: 0017145	41
GO: Hematopoietic stem cell proliferation	GO: 0071425	23
GO: Positive regulation of stem cell differentiation	GO: 2000738	20
GO: Regulation of stem cell population maintenance	GO: 2000036	28
GO: Neuronal stem cell population maintenance	GO: 0097150	22
GO: Regulation of stem cell proliferation	GO: 0072091	67
GO: Somatic stem cell division	GO: 0048103	24
GO: Stem cell differentiation	GO: 0048863	248
GO: Positive regulation of stem cell proliferation	GO: 2000648	40
GO: Regulation of stem cell differentiation	GO: 2000736	112
GO: Hematopoietic stem cell migration	GO: 0035701	6
GO: Stem cell fate commitment	GO: 0048865	9
GO: Mesenchymal stem cell maintenance involved in nephron morphogenesis	GO: 0072038	6
GO: Mesenchymal stem cell differentiation	GO: 0072497	8
GO: Mesenchymal stem cell proliferation	GO: 0097168	5
GO: Asymmetric stem cell division	GO: 0098722	10
GO: Regulation of hematopoietic stem cell proliferation	GO: 1902033	9
GO: Positive regulation of hematopoietic stem cell proliferation	GO: 1902035	5
GO: Negative regulation of stem cell population maintenance	GO: 1902455	8
GO: Positive regulation of stem cell population maintenance	GO: 1902459	8
GO: Regulation of somatic stem cell population maintenance	GO: 1904672	7
GO: Negative regulation of somatic stem cell population maintenance	GO: 1904673	5
GO: Regulation of stem cell division	GO: 2000035	10
GO: Regulation of mesenchymal stem cell differentiation	GO: 2000739	6
Reactome transcriptional regulation of pluripotent stem cells	R-HSA-452723	31

GO: Gene Ontology.

Citation: Yuan Y, Zhang XF, Li YC, Chen HQ, Wen T, Zheng JL, Zhao ZY, Hu QY. VX-509 attenuates the stemness characteristics of colorectal cancer stem-like cells by regulating the epithelial-mesenchymal transition through Nodal/Smad2/3 signaling. World J Stem Cells 2024; 16(2): 207-227
URL: https://www.wjgnet.com/1948-0210/full/v16/i2/207.htm
DOI: https://dx.doi.org/10.4252/wjsc.v16.i2.207