Extracellular vesicles derived from mesenchymal stem cells mediate extracellular matrix remodeling in osteoarthritis through the transport of microRNA-29a

Table 2 The Lequesne MG rating criteria

	Level 1	Level 2	Level 3	Level 4
Pain conditions	No significant reaction	Avoidance contraction of the affected limb following compression	Avoided contraction of the affected limb and turn back, body out present tremor	Violent contraction of the affected limb, violent shaking and struggling of the body
Gait	Normal gait	Mild limp but strong stirring of the affected limb	The limp is pronounced, and the strength of the affected limb to stir on the ground is reduced	The affected limb is afraid to walk on the ground
Knee range of motion	> 90°	45°-90°	15°-45°	< 15°
Swelling	No swelling and clear bony markings	Mild swelling with superficial bony markings	Significant swelling and loss of bony markings