Exosomes derived from microRNA-540-3p overexpressing mesenchymal stem cells promote immune tolerance via the CD74/nuclear factor-kappaB pathway in cardiac allograft

Figure 5 Bone marrow mesenchymal stem cell^{miR-540-3p-mimic} exosomes reduces immune resistance in T cells. A-C: Flow cytometry analysis of the positive rate of CD4⁺ T cells, CD8⁺ T cells, and regulatory T cells for 72 hours; D-G: Enzyme-linked immunosorbent assay-based quantitative analysis of cytokine production (interleukin-1β, interferon-γ, interleukin-10, and transforming growth factor β1) in T cells. ^dP < 0.0001. BMSC: Bone marrow mesenchymal stem cell; LPS: Lipopolysaccharide; exo: Exosomes; IL: Interleukin; TGF: Transforming growth factor; IFN: Interferon.