Efficacy of serum-free cultured human umbilical cord mesenchymal stem cells in the treatment of knee osteoarthritis in mice

Figure 3 Reduced interleukin-6 and interleukin-1β expression in the experimental group. A: Baseline analysis: There was no statistically significant difference in the initial levels of interleukin (IL)-1β among the groups of animals; B: Baseline analysis: There was no statistically significant difference in the initial levels of IL-6 among the groups of animals; C: Model validation: The level of IL-1β in the model control group was significantly higher than that in the sham surgery group (blank control group); D: Model validation: The level of IL-6 in the model control group was significantly higher than that in the sham surgery group (blank control group); E: Experimental endpoints: The level of IL-1β in the experimental group was significantly higher than that in the model control group; F: Experimental endpoints: The level of IL-6 in the experimental group was significantly higher than that in the model control group. ^aP < 0.05, comparison with the sham operated group; ^bP < 0.01, comparison with the sham operated group; ^cP < 0.05, comparison with the model control group; ^dP < 0.01, comparison with the model control group. N-hUCMSCs: Serum-free human umbilical cord mesenchymal stems; S-hUCMSCs: Serum-cultured human umbilical cord mesenchymal stem cells; IL: Interleukin.