Yes-associated protein-mediated melatonin regulates the function of periodontal ligament stem cells under oxidative stress conditions

Figure 4 Melatonin improved proliferative capacity and reduced oxidative stress levels in hydrogen peroxide-induced periodontal ligament stem cells. A: Melatonin (MT) restored the growth state and enhanced the proliferative capacity of hydrogen peroxide (H₂O₂)-induced periodontal ligament stem cells (PDLSCs); B: MT reduced the proportion of G0/G1 phase and increased the proportion of G2/M phase in H₂O₂-induced PDLSCs; C: MT decreased the reactive oxygen species fluorescence intensity of H₂O₂-induced PDLSCs; D: MT decreased the proportion of reactive oxygen species-positive cells in H₂O₂-induced PDLSCs. Data are presented as mean ± SD, n = 3. ^aP < 0.05; ^bP < 0.01; ^dP < 0.0001. NS: No significance; H₂O₂: Hydrogen peroxide; MT: Melatonin; NC: Negative control.