Effects of miR-214-5p and miR-21-5p in hypoxic endometrial epithelial-cell-derived exosomes on human umbilical cord mesenchymal stem cells

Figure 5 Signal transducer and activator of transcription 3 and protein inhibitor of activated signal transducer and activator of transcription 3 are the targets of miR-21-5p and miR-214-5p, respectively. A and B: Relative luciferase activities assessed by dual-luciferase reporter assay; C-H: MiR-21-5p, miR-214-5p, signal transducer and activator of transcription 3 (STAT3), and PIAS3 mRNA expression detected by reverse transcription-quantitative polymerase chain reaction; I: Western blot analysis of STAT3 and phospho (p)-STAT3 protein levels. n = 3. NS: No significant difference, ^aP < 0.05, ^bP < 0.01, ^dP < 0.0001. Data are described as the mean ± SD. STAT3: Signal transducer and activator of transcription 3; NC: Normal control.