Effects of miR-214-5p and miR-21-5p in hypoxic endometrial epithelial-cell-derived exosomes on human umbilical cord mesenchymal stem cells

Figure 3 Differentially expressed microRNAs in human umbilical cord mesenchymal stem cells cocultured with exosomes derived from hypoxia-damaged endometrial epithelial cells. Human umbilical cord mesenchymal stem cells were cocultured with exosomes derived from endometrial epithelial cells or exosomes derived from hypoxia-damaged endometrial epithelial cells. A: Heat map from microRNA sequencing analysis showed microRNA profiles that were differentially expressed in human umbilical cord mesenchymal stem cells treated with exosomes derived from hypoxia-damaged endometrial epithelial cells or exosomes were isolated from normal endometrial epithelial cells; B and C: Reverse transcription-quantitative polymerase chain reaction for detecting miR-214-5p and miR-21-5p. n = 3. NS: No significant difference, ^bP < 0.01, ^cP < 0.001, ^dP < 0.0001. Data are described as the mean ± SD. HucMSC: Human umbilical cord mesenchymal stem cells; EEC-ex: Exosomes isolated from normal endometrial epithelial cells; EECD-ex: Exosomes derived from hypoxia-damaged endometrial epithelial cells.