Integrin beta 3-overexpressing mesenchymal stromal cells display enhanced homing and can reduce atherosclerotic plaque

Figure 5 Mesenchymal stem cell^ITGB3 modulated cytokine expressions in an atherosclerotic mouse model. A: Serum pro-inflammatory factors tumor necrosis factor (TNF)α, interleukin (IL)-1β, and IL-6 and anti-inflammatory factors IL-4, IL-10, and tumor necrosis factor-stimulated gene-6 (TSG-6) levels measured using ELISA; B: mRNA expression of pro-inflammatory factors TNFα, IL-1β, and IL-6 and anti-inflammatory factors IL-4, IL-10, and TSG-6 in aortic tissue, quantified using quantitative real-time polymerase chain reaction. Expression is shown relative to the expression of housekeeping genes (β-actin). All values are expressed as mean ± SEM. ^aP < 0.05, ^bP < 0.001. ELISA: Enzyme-linked immunosorbent assay; IL: Interleukin; MSC: Mesenchymal stem cell; qRT-PCR: Quantitative real-time polymerase chain reaction; SEM: Standard error of the mean; TNF-α: Tumor necrosis factor-a; TSG-6: Tumor necrosis factor-stimulated gene-6.