Integrin beta 3-overexpressing mesenchymal stromal cells display enhanced homing and can reduce atherosclerotic plaque

Figure 4 Injection of mesenchymal stem cell^ITGB3 attenuates atherosclerotic in vivo. A: Representative en face images of mouse aortas stained with Oil Red O (ORO); B: Quantification of the atherosclerotic plaque area as a ratio of the stained area to the total area of the aorta; C: Representative section of mouse aortic arch and aortic root stained with ORO. The ORO-positive area in the aortic root is shown as the ratio of the stained area to the total area of the aortic sinus; D: Representative section of mouse aortic arch and aortic root stained with Masson staining. The Masson staining-positive area in the aortic arch and aortic root is shown as the ratio of the stained area to the total area of the aortic sinus; E: Representative section of mouse aortic arch and aortic root stained with hematoxylin eosin (HE) staining. The HE staining-positive area in the aortic arch and aortic root is shown as the ratio of the stained area to the total area of the aortic sinus; F: Ultrasonography of the aorta in each group, including representative images, systolic diameter, diastolic diameter, and vessel wall thickness; G: Representative images of aortic arch section stained with anti-F4/80 antibody. The F4/80-positive area in the atherosclerotic plaque is shown as the ratio of the stained area to the total area of the atherosclerotic plaque. Scale bar = 100 μm. ^aP < 0.05, ^bP < 0.001. AS: Atherosclerotic; HE: Hematoxylin eosin; MSC: Mesenchymal stem cell; ORO: Oil Red O.