Interferon-γ priming enhances the therapeutic effects of menstrual blood-derived stromal cells in a mouse liver ischemia-reperfusion model

Figure 9 Schematic depiction of the mechanism. Ischemia-reperfusion injury (IRI) and immune rejection are two important factors that affect the prognosis of liver transplantation. After priming menstrual blood-derived stromal cells (MenSCs) with interferon-γ, the MenSCs secreted high levels of indoleamine 2,3-dioxygenase (IDO). On the one hand, MenSCs and IDO enhanced the AMPK-mammalian target of rapamycin-autophagy axis to reduce IRI; on the other hand, IDO promoted the differentiation of lymphocytes into Tregs to reduce immune rejection. IRI: Ischemia-reperfusion injury; MenSCs: Menstrual blood-derived stromal cells; IFN-γ: Interferon-γ; IDO: Indoleamine 2,3-dioxygenase; AMPK: AMP-activated protein kinase signaling pathway; mTOR: Mammalian target of rapamycin signaling pathway; Tregs: Regulatory T cells.