Interferon-γ priming enhances the therapeutic effects of menstrual blood-derived stromal cells in a mouse liver ischemia-reperfusion model

Figure 5 Metabolomic data analysis. A: Heatmap of 45 differential metabolites between the ischemia-reperfusion (IR) group and IRM (interferon-γ) group; B: Volcano plot of 45 differential metabolites; C: The relevant pathways in which the differential metabolites are involved were analyzed by comparing the information in the Kyoto Encyclopedia of Genes and Genomes database; D: The main biological functions of differential metabolites were elucidated by pathway enrichment analysis; E: Relative quantitation of the differential metabolite phosphatidyl ethanolamine was performed to measure the effect of primed menstrual blood-derived stromal cells on the level of autophagy in liver tissues. MenSCs: Menstrual blood-derived stromal cells; IFN-γ: Interferon-γ; IR: Ischemia-reperfusion; IRM(IFN-γ) or IRPM: Combination treated with ischemia-reperfusion and interferon-γ-primed menstrual blood-derived stromal cells; PE: Phosphatidyl ethanolamine; OS: Organismal systems; M: Metabolism; HD: Human diseases; CP: Cellular processes; EIP: Environmental information processing; KEEG: Kyoto Encyclopedia of Genes and Genomes.