Transplantation of human induced pluripotent stem cell derived keratinocytes accelerates deep second-degree burn wound healing

Figure 1 Screening based on GEO datasets identified high expression of COL7A1 in human induced pluripotent stem cells derived keratinocytes and low expression in burn wounds. A: Volcano plot of differentially expressed genes (DEGs) in GSE140926 dataset, which included 3 normal skin tissue samples and 3 burn eschar tissue samples. Abscissa axis indicates log2 (Fold change); B: Volcano plot of DEGs in GSE27186 dataset, which included 2 human induced pluripotent stem cells (hiPSCs) samples and 2 hiPSCs- keratinocytes samples. Abscissa axis indicates log2 (Fold change); C: The venn diagram exhibited the intersection of the downregulated DEGs in the GSE140926 dataset and the upregulated DEGs in the GSE27186 dataset; D: Gene ontology (GO) entry enrichment bar plot. Abscissa is the proportion of genes identified and ordinate is the GO entry name; E: Visualization of significant DEGs enriched in GO-biological pathway (BP) entries; F: Visualization of significant DEGs enriched in GO-cellular component entries. G: Visualization of significant DEGs enriched in GO-MF entries; H: The Venn diagram exhibited the intersection of GO-BP, GO-CC, and GO-MF; I: Heatmap of the 4 DEGs in GSE140926.