Review
Copyright ©The Author(s) 2023.
World J Stem Cells. Jul 26, 2023; 15(7): 665-686
Published online Jul 26, 2023. doi: 10.4252/wjsc.v15.i7.665
Table 3 Key molecules of the mesenchymal secretome derived from different cell types in the treatment and regeneration of retinal cells
MSC
MSC secretome
Müller glia cell secretome
RPE cell secretome
Other retinal cell secretome
IFN-γ[8]IFN-γ[8]TSP-1[131]VEGF[68]TSP-1[131]
VEGF[10]VEGF[10]PEDF[70]TGF-β[69]PEDF[70]
PIGF[81]PIGF[81]IL-1b[11]PEDF[70]IL-1b[11]
SDF-1[10]SDF-1[10]IL-1R[143]MMPs[71]IL-1R[143]
ANG2[10]ANG2[10]TNF-α[11]NGF[72]IL-6[11]
G-CSF[10]G-CSF[10]IL-4[134]FGF-1[73]TNF-α[11]
SCF[10]SCF[10]IL-6[134]FGF-2[73]IL-4[134]
PDGF[10]PDGF[10]IL-10[134]FGF-5[73]IL-10[134]
EGF[10]EGF[10]VEGF[10]IGF-1[74]VEGF[10]
HGF[10]HGF[10]IFN-γ[8]BDNF[75]IFN-γ[8]
IGF-1[10]IGF-1[10]TGF-β1[34]PDGF[76]TGF-β1[34]
TNF-α[11]TNF-α[11]TGF-β2[34]CTGF[77]TGF-β2[34]
IL-1b[11]IL-1b[11]TGF-β3[34]LEDGF[78]TGF-β3[34]
IL-2[11]IL-2[11]MMPs[71]IL-1b[79]MMPs[71]
IL-3[11]IL-3[11]CLU[121]IL-2[79]CLU[121]
IL-6[11]IL-6[11]SPP1[142]IL-3[79]SPP1[142]
IL-8[11]IL-8[11]BSG[142]IL-6[79]BSG[142]
CCL5[11]CCL511AQP4[143]IL-8[79]AQP4[143]
CCL2[11]CCL2[11]RLBP1[143]TIMP[80]RLBP1[143]
TGF-β[18]SLC1A3[143]PIGF[81]SLC1A3[143]
FGF[18]KCNJ1[143]ANGIOGENIN[82]KCNJ1[143]
NGF-β[18]KCNJ10[143]EPO[83]KCNJ10[143]
CXCL12[19]ANG2[143]SOMATOSTATIN[84]ANG2[143]
miR-210[44]ENDOGLIN[143]APOA1[85]ENDOGLIN[143]
miR-200b-3p[44]CXCL8[39]APOE[116]CXCL8[143]
miR146a[46]PDGF[10]TGF-β[69]PDGF[76]
miR27a/b[46]VAMP5[144]BMP1[116]VAMP5[144]
miR-122-5p[46]HTRA1[129]TGF-β[69]
miR-206[46]NGF[72]
MALAT[46] (lncRNA)FGF-1[73]
FGF-2[73]
FGF-5[73]
IGF-1[74]
BDNF[75]
PDGF[76]
CTGF[77]
LEDGF[78]
IL-2[79]
IL-3[79]
IL-8[79]
TIMP[80]
PIGF[81]
ANGIOGENIN[82]
EPO[83]
SOMATOSTATIN[84]
APOA1[85]
APOE[116]
BMP1[116]
HTRA1[129]
MSC: Mesenchymal stem cell; RPE: Retinal pigment epithelium; FGF: Fibroblast growth factor; NGF: Nerve growth factor.