Human retinal secretome: A cross-link between mesenchymal and retinal cells

Table 1 Ongoing clinical trials on eye diseases based on the use of mesenchymal stem cells

Title	Sponsor/collaborators	URL
Safety and Efficacy of Pluripotent Stem Cell-derived Mesenchymal Stem Cell Exosome (PSC-MSC-Exo) Eye Drops Treatment for Dry Eye Diseases Post Refractive Surgery and Associated With Blepharospasm	Second Affiliated Hospital, School of Medicine, Zhejiang University|Zhejiang University|Hangzhou yuansheng biotechnology Co., Ltd	https://ClinicalTrials.gov/show/NCT05738629
Therapeutic Effect of Stem Cell Eye Drops on Dry Eye Disease	The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School	https://ClinicalTrials.gov/show/NCT05784519
Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cells for Eye Diseases	The Foundation for Orthopaedics and Regenerative Medicine	https://ClinicalTrials.gov/show/NCT05147701
The Role of Transscleral Cyclophotocoagulation in Patients Undergoing a Boston Keratoprosthesis	Centre hospitalier de l’Universitè de Montreal (CHUM)|Fonds de recherche en ophtalmologie de l'Universitè de Montreal	https://ClinicalTrials.gov/show/NCT04232982
Characterization of Potential Biomarkers of Eye Disease and Vision	Association for Innovation and Biomedical Research on Light and Image	https://ClinicalTrials.gov/show/NCT02500862
Long-term Safety of UC-MSC Transplantation in Patients With Retinitis Pigmentosa	PT. Prodia Stem Cell Indonesia	https://ClinicalTrials.gov/show/NCT05786287
Clinical Evaluation of Two Daily Disposable Lenses in Sphere Design	Coopervision, Inc.	https://ClinicalTrials.gov/show/NCT05516082
Efficacy of Locally Delivered Allogeneic Mesenchymal Stromal Cells	University of Illinois at Chicago|United States Department of Defense	https://ClinicalTrials.gov/show/NCT05705024
Diquafosol vs Hyaluronic Acid for Diabetic Dry Eye	He Eye Hospital	https://ClinicalTrials.gov/show/NCT05682547
Eye Length Signal With Myopia Control	Brien Holden Vision Institute	https://ClinicalTrials.gov/show/NCT04813640
Patient Acceptability of Autonomous Telemedicine	Ufonia|Buckinghamshire Healthcare NHS Trust|Innovate UK	https://ClinicalTrials.gov/show/NCT04885868
Phase 2b Pivotal Study of Izokibep in Non-infectious, Intermediate-, Posterior- or Pan-uveitis	ACELYRIN Inc.	https://ClinicalTrials.gov/show/NCT05384249
Dose Optimization for Safe and Efficient Fluorescein Angiography (DOSE Study)	Seoul National University Bundang Hospital	https://ClinicalTrials.gov/show/NCT05664555
Analysis of the Results of Intense Pulsed Light Treatment Previously to Laser Refractive Surgery	Vissum, Instituto Oftalmologico de Alicante	https://ClinicalTrials.gov/show/NCT05139511
Study of the Association Between Digital Eye Syndrome With Binocular Vision and the Ocular Surface in Higher Education Students in the Area of Health Technologies	Universidade Nova de Lisboa|NOVA Medical School Faculdade de Cinecias Medicas, Universidade Nova de Lisboa|Escola Superior de Tecnologia da Salude de Lisboa (ESTeSL)|University of lâvora|CINTESIS@RISE, NOVA Medical School Faculdade de Ciencias Medicas, Universidade Nova de Lisboa|Comprehensive Health Research Center (CHRC), Universidade Nova de Lisboa	https://ClinicalTrials.gov/show/NCT05675475
Caffeine Consumption and Cataract Prevention	Vienna Institute for Research in Ocular Surgery	https://ClinicalTrials.gov/show/NCT05194696
Rotational Stability of the TECNIS Eyhance Toric	Vienna Institute for Research in Ocular Surgery	https://ClinicalTrials.gov/show/NCT05126368
Reading Performance in Patients With Acrysof IQ Vivity Versus Acrysof IQ	Vienna Institute for Research in Ocular Surgery	https://ClinicalTrials.gov/show/NCT05194657
Performance of Two Intraocular Lenses With Extended Depth of Vision	Vienna Institute for Research in Ocular Surgery	https://ClinicalTrials.gov/show/NCT05194150
Assessment of Retinal Vascular Changes With and Without ILM Peeling in Diabetic Vitrectomy Using OCT-A	Kasr El Aini Hospital	https://ClinicalTrials.gov/show/NCT05739539
Primary Vitrectomy With Silicone Oil or SF6 for Rhegmatogenous Retinal Detachment	Cairo University	https://ClinicalTrials.gov/show/NCT05377606
Intravitreal Sirolimus as Therapeutic Approach to Uveitis	Stanford University|Santen Inc.	https://ClinicalTrials.gov/show/NCT01280669
Clinical Trial With Artiflex Presbyopic	Ophtec BV	https://ClinicalTrials.gov/show/NCT04632784
Post-Market Evaluation of the EVO ICL	Staar Surgical Company	https://ClinicalTrials.gov/show/NCT05538754
Clinical Evaluation of Two Multifocal Contact Lenses	Coopervision, Inc.	https://ClinicalTrials.gov/show/NCT05457608
Ologen Collagen Matrix Versus Mitomycin-C in Patients With Juvenile-onset Open Angle Glaucoma	L.V. Prasad Eye Institute	https://ClinicalTrials.gov/show/NCT03548805
A Comparative Study of Visual Outcome of Two Extended Depth of Focus Intraocular Lenses After Cataract Surgery	Cairo University	https://ClinicalTrials.gov/show/NCT05647421
Keratometric Change After XEN, Trabeculectomy and Tube Shunts	Centre hospitalier de l'Universitè de Montreal (CHUM)|Allergan	https://ClinicalTrials.gov/show/NCT04602923
Post-market Follow Up Study on Paragon CRT 100 (Paflufocon D)	Coopervision, Inc.|TigerMed	https://ClinicalTrials.gov/show/NCT04187599
Evaluating Two Multifocal Daily Disposable Contact Lenses	Coopervision, Inc.	https://ClinicalTrials.gov/show/NCT05579886
A Clinical Comparison of Two Soft Multifocal Contact Lenses	Coopervision, Inc.	https://ClinicalTrials.gov/show/NCT05794126
Ocular Surface Disease and IOP Monitoring With Travoprost Without Conservatives	Democritus University of Thrace	https://ClinicalTrials.gov/show/NCT05319470
Performance of Two Hydrophobic IOLs	Vienna Institute for Research in Ocular Surgery	https://ClinicalTrials.gov/show/NCT05639049
RayOne EMV Mini-monovision - Efficiency and Safety of 3 Grades of Mini-monovision	Somich, s.r.o.	https://ClinicalTrials.gov/show/NCT05417633
A Clinical Study to Evaluate the Potential Role of ACTH Gel in Patients With Scleritis	Metropolitan Eye Research & Surgery Institute|Mallinckrodt|Stanford University|Ocular Imaging Research and Reading Center|Foresight Studies, LLC	https://ClinicalTrials.gov/show/NCT03465111
Zimbabwe Eyecare And Learning (ZEAL): Formative Research on Hyperopia and Educational Outcomes in Primary School Children	Queen's University, Belfast|L.V. Prasad Eye Institute|University of Zimbabwe|University of Ulster|New England College of Optometry|Peek Vision|Zimbabwe Optometric Association|Clearly|Christian Blind Mission	https://ClinicalTrials.gov/show/NCT05538182
Vision and Balance Changes After Bilateral Implantation of Toric IOLs	University of Plymouth|Carl Zeiss Meditec AG|Glasgow Caledonian University|University of St Mark and St John Plymouth|University Hospital Plymouth NHS Trust	https://ClinicalTrials.gov/show/NCT05629078
Multicenter Study on the Efficacy and Safety of OCS-01 in Subjects With Uveitis Related and Post Surgical Macular Edema	Quan Dong Nguyen|Global Ophthalmic Research Center (GORC)|Oculis|Stanford University	https://ClinicalTrials.gov/show/NCT05608837
Inflammatory Biomarkers in Ocular Surface in Primary Open Angle Glaucoma or Ocular Hypertension Under Topical Prostaglandins	Instituto Universitario de Oftalmobiologia Aplicada (Institute of Applied Ophthalmobiology) - IOBA|Hospital Clvinico Universitario de Valladolid	https://ClinicalTrials.gov/show/NCT05039684
Ranibizumab vs Bevacizumab for Type 1 Retinopathy of Prematurity	Zagazig University|Cairo University	https://ClinicalTrials.gov/show/NCT05033106
Dresden Corneal Disease and Treatment Study	Technische Universitut Dresden	https://ClinicalTrials.gov/show/NCT04251143
Reliability, Validity of the Turkish Version of the Primary Sjogren Syndrome Quality of Life (PSS-QoL) Questionnaire	Gazi University	https://ClinicalTrials.gov/show/NCT04858464
Mean Visual Acuity Changes Following Five Injections of Aflibercept	McMaster University	https://ClinicalTrials.gov/show/NCT02645266
Targeted Fluorescence Imaging in AMD	University Medical Center Groningen	https://ClinicalTrials.gov/show/NCT05262244
Treatment of Ligneous Conjunctivitis in Children With Plasminogen Deficiency	University of Saskatchewan|Canadian Blood Services	https://ClinicalTrials.gov/show/NCT05404932
Can the Risk for AMD be Modulated?	Association for Innovation and Biomedical Research on Light and Image	https://ClinicalTrials.gov/show/NCT05735730
Study to Evaluate the Response to Supplementation With Postbiotics in Patients With Macular Degeneration	Institut de la Macula y la Retina|Igen BioLab SLU	https://ClinicalTrials.gov/show/NCT05056025
Development of a Tele-Physiotherapy Tool for the Early Management of Muskuloskeletal Pain in People With Visual Impairement (TeleEDxPhysio)	Escuela Universitaria de Fisioterapia de la Once|Universidad de Zaragoza	https://ClinicalTrials.gov/show/NCT05478200
Clinical Trial to Evaluate Safety and Efficacy of Cell Therapy in Patients With Cicatricial Conjuntivitis	Instituto de Investigacion Sanitaria de la Fundacion Jimenez Diaz|Effice Servicios Para la Investigacion S.L	https://ClinicalTrials.gov/show/NCT05520086
Advanced Glaucoma Progression Study	University of California, Los Angeles|National Eye Institute (NEI)	https://ClinicalTrials.gov/show/NCT01742819
Retrobulbar Methylprednisolone as Adjunctive Treatment in Optic Neuritis Trial	Asociacion para Evitar la Ceguera en Mexico	https://ClinicalTrials.gov/show/NCT04942002
Nystagmus Assessment for Patients Consulting in the Emergency Department for Acute Vertigo	CHU de Quebec-Universite Laval	https://ClinicalTrials.gov/show/NCT05176015
Effectiveness of Periocular Drug Injection in CATaract Surgery	Luigi Rondas|European Society of Cataract and Refractive Surgeons|Academisch Ziekenhuis Maastricht	https://ClinicalTrials.gov/show/NCT05158699
Clinical Trial Comparing Two Non-Surgical Treatments for Severe Blepharoptosis	Massachusetts Eye and Ear Infirmary|National Eye Institute (NEI)	https://ClinicalTrials.gov/show/NCT04678115
Stem Cell Ophthalmology Treatment Study II	MD Stem Cells	https://ClinicalTrials.gov/show/NCT03011541
Effect of Intravenous Methylprednisolone and Intravenous Erythropoietin in Toxic Optic Neuropathies: Randomized Clinical Trial	Asociacion para Evitar la Ceguera en Mexico	https://ClinicalTrials.gov/show/NCT05748561
SPT Screening in Irradiated Hereditary Retinoblastoma Survivors	Amsterdam UMC, location VUmc|ODAS	https://ClinicalTrials.gov/show/NCT02329002
Community Access Through Remote Eyesight (CARE) Study	New England College of Optometry|National Institute on Disability, Independent Living, and Rehabilitation Research|University of California, Los Angeles	https://ClinicalTrials.gov/show/NCT04926974
Electro-acupuncture and Transcorneal Electrical Stimulation (TES) for Retinitis Pigmentosa	Nova Southeastern University|National Eye Institute (NEI)	https://ClinicalTrials.gov/show/NCT02086890
Evaluation of NeoRetina Artificial Intelligence Algorithm for the Screening of Diabetic Retinopathy at the CHUM	Centre hospitalier de l'Universitè de Montreal (CHUM)|DIAGNOS Inc.	https://ClinicalTrials.gov/show/NCT04699864
Clemastine Fumarate as Remyelinating Treatment in Internuclear Ophthalmoparesis and Multiple Sclerosis	Amsterdam UMC, location VUmc	https://ClinicalTrials.gov/show/NCT05338450
The K-Map Study, Global Prevalence of KC	University Hospital, Geneva|ELZA Institute	https://ClinicalTrials.gov/show/NCT03115710
Methotrexate For The Prevention and Treatment of Proliferative Vitreoretinopathy in Pediatric Patients	Stanford University	https://ClinicalTrials.gov/show/NCT04830878
A Collaborative Resource of Heidelberg Multimodal Imaging of Intermediate and Early Atrophic AMD Cases to Study Prediction of Disease Progression	Association for Innovation and Biomedical Research on Light and Image|European Vision Institute Clinical Research Network	https://ClinicalTrials.gov/show/NCT05698316
Clinical Trial of Multi-Periscopic Prism Glasses for Hemianopia	Massachusetts Eye and Ear Infirmary|National Eye Institute (NEI)	https://ClinicalTrials.gov/show/NCT04827147
Feasibility Tests for Various Prism Configurations for Visual Field Loss	Massachusetts Eye and Ear Infirmary|National Eye Institute (NEI)	https://ClinicalTrials.gov/show/NCT04424979
Quality Assurance Via Telephone Interviews After Cataract Surgery	Vienna Institute for Research in Ocular Surgery	https://ClinicalTrials.gov/show/NCT05215002
0.01% Hypochlorous Acid in the Treatment of Blepharitis	Eye & ENT Hospital of Fudan University|ShuGuang Hospital	https://ClinicalTrials.gov/show/NCT05608980
Birdshot Chorioretinopathy: Prospective Follow-up and Immunogenetic Studies(CO-BIRD)	Assistance Publique - Hopitaux de Paris	https://ClinicalTrials.gov/show/NCT05153057
Characterization of Retinal Disease Progression in Eyes With Non Proliferative Diabetic Retinopathy in Diabetes Type 2 Using Non-invasive Procedures (CHART)	Association for Innovation and Biomedical Research on Light and Image|European Vision Institute Clinical Research Network	https://ClinicalTrials.gov/show/NCT04636307
Swiss Pediatric Inflammatory Brain Disease Registry (Swiss-Ped-IBrainD)	University of Bern|Schweizerische Multiple Sklerose Gesellschaft|University Hospital Inselspital, Berne|Roche Pharma (Switzerland) Ltd|Novartis	https://ClinicalTrials.gov/show/NCT05017142
Topotecan Episcleral Plaque for Treatment of Retinoblastoma	Targeted Therapy Technologies, LLC	https://ClinicalTrials.gov/show/NCT04156347
Comparison of Phacoemulsification and Corneal Damage Between FLACS and Standard Phaco With Two Handpieces	Centre hospitalier de l'Universitè de Montreal (CHUM)	https://ClinicalTrials.gov/show/NCT05119270
Computer-based Tutorial and Automated Speech Recognition for Intravitreal Drug Injections	Prim. Prof. Dr. Oliver Findl, MBA|Vienna Institute for Research in Ocular Surgery	https://ClinicalTrials.gov/show/NCT04142164
OCS-05 in Patients With Acute Optic Neuritis	Oculis|Neurotrials	https://ClinicalTrials.gov/show/NCT04762017
PROgressive Supranuclear Palsy CorTico-Basal Syndrome Multiple System Atrophy Longitudinal Study UK	University College, London|University of Cambridge|University of Oxford|University of Manchester|Newcastle University|University of Sussex|Royal Gwent Hospital	https://ClinicalTrials.gov/show/NCT02778607
Therapeutic Recommendations For The Treatment Of Children With A Retinoblastoma	French Africa Pediatric Oncology Group	https://ClinicalTrials.gov/show/NCT04425434
Temperature on Evaporative Dry Eye	He Eye Hospital	https://ClinicalTrials.gov/show/NCT05720754
Prevalence of Visual Dysfunction in Neurological Disorders	University of Florida	https://ClinicalTrials.gov/show/NCT04836715
Intravitreal Infliximab for Proliferative Vitreoretinopathy	Cairo University	https://ClinicalTrials.gov/show/NCT04891991
A Patch Free Treatment for Young Children With Amblyopia	University of Waterloo|Retina Foundation of the Southwest|McGill University|Queensland University of Technology	https://ClinicalTrials.gov/show/NCT04086524
Effectiveness of the Serious Game 'Broodles' for Siblings of Children With Visual Impairment and/or Intellectual Disability	VU University of Amsterdam	https://ClinicalTrials.gov/show/NCT05376007
Screening for Oculocerebral Lymphoma With the Phenotype of NK Cells in Patients With Uveitis	Hospices Civils de Lyon	https://ClinicalTrials.gov/show/NCT05388838
10-year Progression of Diabetic Retinopathy: Identification of Signs and Surrogate Outcomes	Association for Innovation and Biomedical Research on Light and Image	https://ClinicalTrials.gov/show/NCT04650165
Management of DE With IPL in Combination With DQS	He Eye Hospital	https://ClinicalTrials.gov/show/NCT05694026
Endophthalmitis Post Intravitreal Injections	Rajeev Muni|Unity Health Toronto	https://ClinicalTrials.gov/show/NCT04035369
Discovering Early Biomarkers in Circulating Endothelial Cells for Diabetes Complications by Single Cell RNA Sequencing	Aarhus University Hospital|University of Aarhus	https://ClinicalTrials.gov/show/NCT05169502
Diabetic Retinopathy Classification: ETDRS 7-fields vs Widefield Imaging (ClarusDR)	Association for Innovation and Biomedical Research on Light and Image	https://ClinicalTrials.gov/show/NCT05746975
Evaluation of Desensitization Therapy and Re-treatment of Eye Movement Information [EMDR] in Patients With Post-traumatic Stress Disorder [PTSD]	Centre hospitalier de Ville-Evrard, France	https://ClinicalTrials.gov/show/NCT04431765
Prediction of Progression of Retinal Ischemia in Diabetes	Association for Innovation and Biomedical Research on Light and Image	https://ClinicalTrials.gov/show/NCT05581225
Personalized Parkinson Project PSP Cohort	Radboud University Medical Center|UCB Pharma|Verily Life Sciences LLC	https://ClinicalTrials.gov/show/NCT05501431
Enriched Eggs for Retina Health in Type 2 Diabetes	University of Manitoba|Egg Farmers of Canada	https://ClinicalTrials.gov/show/NCT04496817
Pneumatic Retinopexy Versus Vitrectomy for Retinal Detachment in Patients With Extended Criteria	Unity Health Toronto	https://ClinicalTrials.gov/show/NCT02871531
Adherence to Lifestyle Changes for Age-related Macular Degeneration	Erasmus Medical Center|CORR foundation	https://ClinicalTrials.gov/show/NCT05667441
Timing of Glaucoma Drainage Device With Boston Keratoprosthesis	Centre hospitalier de l'Universitè de Montreal (CHUM)	https://ClinicalTrials.gov/show/NCT02084745
Patient Satisfaction and Visual Function Following Implantation of Trifocals or Extended Range of Vision Intraocular Lenses	Queen's University|University of Toronto	https://ClinicalTrials.gov/show/NCT04900662
A Computerized, Adaptive Therapeutic Gaming Approach Training Visual Perceptual Skills in Children With CVI	Universitaire Ziekenhuizen KU Leuven|Vrije Universiteit Brussel|Fund for Scientific Research, Flanders, Belgium	https://ClinicalTrials.gov/show/NCT05014503
Re-Orchestration of Interregional Oscillatory Activity to Promote Visual Recovery	Ecole Polytechnique Federale de Lausanne	https://ClinicalTrials.gov/show/NCT05220449
Effect of Type of Head Positioning on Retinal Displacement in Vitrectomy for Retinal Detachment	Unity Health Toronto	https://ClinicalTrials.gov/show/NCT04035343
Macular Perfusion Changes After Anti-VEGF Versus Targeted Retinal Photocoagulation in Proliferative Diabetic Retinopathy	Cairo University	https://ClinicalTrials.gov/show/NCT04674254
Metabo-lipidomics of the Ocular Surface for Cataract Surgery	University Hospital, Tours	https://ClinicalTrials.gov/show/NCT05802550
Macular Involvement in Diabetic Retinopathy Evaluated With Swept-Source OCT	University of British Columbia	https://ClinicalTrials.gov/show/NCT03765112
EyeConic: Qualification for Cone-Optogenetics	University Hospital, Basel, Switzerland|Institute of Molecular and Clinical Ophthalmology Basel	https://ClinicalTrials.gov/show/NCT05294978
Suprachoroidal Visco-buckling for the Treatment of Rhegmatogenous Retinal Detachment	King's College Hospital NHS Trust|Norfolk and Norwich University Trust Foundation|St Thomas' Hospital, London|University of Sunderland|Moorfields Eye Hospital NHS Foundation Trust|Mid and South Essex NHS Foundation Trust|Sheffield Teaching Hospitals NHS Foundation Trust	https://ClinicalTrials.gov/show/NCT04557527
S.T.O.P. Technology Contact Lenses Versus Dual-focus Contact Lenses for Slowing Down Myopia Progression in Children	nthalmic Pty Ltd|Brighten Optix Corporation	https://ClinicalTrials.gov/show/NCT05243836
PMCF Study on EDOF (Isopure) vs Monofocal (Micropure) IOL	Beaver-Visitec International, Inc.|targomedGmbH	https://ClinicalTrials.gov/show/NCT04249492
ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)	Mayo Clinic|University of California, San Francisco|National Institute on Aging (NIA)|National Institute of Neurological Disorders and Stroke (NINDS)	https://ClinicalTrials.gov/show/NCT04363684
Systematic Assessment of Laryngopharyngeal Function in Patients With MSA, PD, and 4 repeat Tauopathies	Kliniken Beelitz GmbH|University Hospital Muenster|Medical University of Warsaw|University Hospital Carl Gustav Carus|University of Ulm|Medical University Innsbruck|Hannover Medical School|University of Barcelona	https://ClinicalTrials.gov/show/NCT04706234