Synergism of calycosin and bone marrow-derived mesenchymal stem cells to combat podocyte apoptosis to alleviate adriamycin-induced focal segmental glomerulosclerosis

Figure 2 Calycosin pretreatment enhances the ability of mesenchymal stem cells to inhibit apoptosis in adriamycin-induced focal segmental glomerulosclerosis mice. A-C: Protein expression levels of Bax and Bcl-2 in the kidneys measured by Western blot and normalized to control. Data are expressed as the mean ± SD (n = 3). ^aP < 0.05, ^bP < 0.001; D: Apoptosis in each group as determined by TUNEL assay. Bar = 50 μm. NC: Normal control; ADR: Adriamycin; MSCs: Mesenchymal stem cells; CA: Calycosin; MSCs^CA: Mesenchymal stem cells pretreated with calycosin.