Neural lineage differentiation of human pluripotent stem cells: Advances in disease modeling

Figure 2 Self-organization of brain organoids. Human brain organoids are generated based on the self-organizing properties of stem cells. Organoids usually contain multiple cell types including mature neurons and immature neural progenitors. The key to organoid regeneration is the extracellular matrix that is used to support stem cell growth and differentiation. Brain organoids have been widely utilized to model neurological pathology in disease such as Alzheimer’s disease and microcephaly.