Stimulating factors for regulation of osteogenic and chondrogenic differentiation of mesenchymal stem cells

doi:10.4252/wjsc.v15.i5.369

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May 26, 2023 (publication date) through Nov 22, 2024

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World Journal of Stem Cells

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1948-0210

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World J Stem Cells. May 26, 2023; 15(5): 369-384
Published online May 26, 2023. doi: 10.4252/wjsc.v15.i5.369

Table 5 Exosomes of different cell sources and their effects on the differentiation of mesenchymal stem cells

Source and kind	Specific cargo	Target	Results	Ref.
M1 macrophages-EVs	miRNA-21a-5p	BMSCs	↑ Osteogenic differentiation	Liu et al[104]
M0 macrophages-EVs		BMSCs	↓ Chondrogenic differentiation	Xia et al[105]
M1 macrophages-EVs		BMSCs	↑ Osteogenic differentiation; ↑ adipogenic differentiation; ↓ chondrogenic differentiation
M2 macrophages-EVs		BMSCs	↓ Chondrogenic differentiation
M2 macrophages-EVs	miRNA-5106	BMSCs;SIK2 and SIK3	↑ Osteogenic differentiation	Xiong et al[106]
M2 macrophages-EVs	miRNA-690	BMSCs	↑ Osteogenic differentiation; ↓ adipogenic differentiation	Li et al[107]
M0 macrophages-EVs		MSCs	↑ Osteogenic differentiation	Kang et al[108]
M1 macrophages-EVs	miRNA-155	MSCs	↓ Osteogenic differentiation
M2 macrophages-EVs	miRNA-378a	MSCs	↑ Osteogenic differentiation
M2 macrophages-EVs	miRNA-26a-5p	BMSCs	↑ Osteogenic differentiation; ↓ adipogenic differentiation	Bin-bin et al[109]
Macrophages-EVs		BMSCs	↓ Osteogenic differentiation	Song et al[103]
Monocytes-EVs		MSCs	↑ Osteogenic differentiation	Ekström et al[110]
Osteoclasts-EVs	miRNA-324	BMSCs	↑ Osteogenic differentiation	Liang et al[111]

↑: Increase; ↓: Decrease; EVs: Extracellular vesicles; MSCs: Mesenchymal stem cells; BMSCs: Bone mesenchymal stem cells; SIK2/SIK3: Salt-inducible kinase 2/3.

Citation: Zhou JQ, Wan HY, Wang ZX, Jiang N. Stimulating factors for regulation of osteogenic and chondrogenic differentiation of mesenchymal stem cells. World J Stem Cells 2023; 15(5): 369-384
URL: https://www.wjgnet.com/1948-0210/full/v15/i5/369.htm
DOI: https://dx.doi.org/10.4252/wjsc.v15.i5.369