Stimulating factors for regulation of osteogenic and chondrogenic differentiation of mesenchymal stem cells

Table 2 Micro RNA and their effects on the differentiation of mesenchymal stem cells

Amount/types	Expression	Cell source	Results	Ref.
micro-RNA-1286	Over expression	hMSCs	↓ Osteogenic differentiation	Zhou et al[27]
micro-RNA-223-3p	Low expression	BMSCs	↑ Osteogenic differentiation	Long et al[28]
micro-RNA-346-5p	Over expression	BMSCs	↓ Osteogenic differentiation	Zhang et al[29]
micro-RNA-21	Over expression	hucMSCs	↑ Osteogenic differentiation	Meng et al[4]
micro-RNA-130a	Over expression	BMSCs	↑ Osteogenic differentiation ↓ adipogenic differentiation	Lin et al[30]
micro-RNA-130b	Low expression	BMSCs	↑ Chondrogenic differentiation	Zhang et al[31]
micro-RNA-218	Over expression	SDSCs	↑ Chondrogenic differentiation during the eraly stage	Chen et al[32]
micro-RNA-495	Over expression	hMSCs	↓ Chondrogenic differentiation	Lee et al[33]
micro-RNA-30a	Over expression	BMSCs	↑ Chondrogenic differentiation	Tian et al[34]
micro-RNA-145	Low expression	ADSCs	↑ Endothelial differentiation	Arderiu et al[26]
micro-RNA-124	Over expression	ADSCs	↑ Neuronal differentiation	Mondanizadeh et al[35]
micro-RNA-10-5p	Low expression	BMSCs	↑ Myocardial differentiation	Li et al[36]
micro-RNA-499a-5p	Over expression	BMSCs	↑ Cardiomyogenic differentiation	Neshati et al[37]

↑: Increase; ↓: Decrease; hMSCs: Human mesenchymal stem cells; BMSCs: Bone mesenchymal stem cells; hucMSCs: Human umbilical cord mesenchymal stem cells; SDSCs: Synovium-derived mesenchymal stem cells; ADSCs: Adipose-derived stem cells.