How the interplay among the tumor microenvironment and the gut microbiota influences the stemness of colorectal cancer cells

doi:10.4252/wjsc.v15.i5.281

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. May 26, 2023; 15(5): 281-301
Published online May 26, 2023. doi: 10.4252/wjsc.v15.i5.281

Table 2 Consensus molecular subtypes of colorectal cancer

	CMS1-immune (14%)	CMS2-canonical (37%)	CMS3-metabolic (13%)	CMS4-mesenchymal (23%)	Unclassified (13%)
General features	Hypermutated	Epithelial	Epithelial	TGF-β activation. Angiogenesis	Mixed phenotype of multiple CMS
General features	Microsatellite unstable	WNT and MYC signaling activation	Metabolic dysregulation	Upregulation of EMT	Mixed phenotype of multiple CMS
Mutations	BRAF, MSH6, RNF43, ATM, TGFBr2, PTEN	APC, KRAS, TP53, PIK3CA	APC, KRAS, TP53, PIK3CA	APC, KRAS, TP53, PIK3CA
TME	Decrease of CAFs	Decrease of CAFs	Decrease of CAFs	Increase of CAFs; Immunosuppressive signature
TME	High immune and inflammatory signature	Low immune and inflammatory signature	Low immune and inflammatory signature	Increase of CAFs; Immunosuppressive signature

This Table is based on Islas et al[1], 2022; Fidelle et al[79], 2020; Trinh et al[169], 2018; Becht et al[78], 2016; Guinney et al[77], 2015. APC: Adenomatous polyposis coli gene; ATM: Ataxia telangiectasia mutated gene; BRAF: Serine/threonine-protein kinase B-raf gene; CAFs: Cancer associated fibroblasts; CMS: Consensus molecular subtype; EMT, Epithelial to mesenchymal transition; KRAS: Ki-ras2 kirsten rat sarcoma viral oncogene homolog gene; MSH6: MutS homolog 6 gene; PIK3CA: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha gene; PTEN: Phosphatase and tensin homolog gene; RNF43: Ring finger protein 43 gene; TGF-β: Transforming growth factor beta; TGFBr2: Transforming growth factor beta receptor 2 gene; TME: Tumor microenvironment; TP53: Transformation-related protein 53 gene.

Citation: Novoa Díaz MB, Carriere P, Gentili C. How the interplay among the tumor microenvironment and the gut microbiota influences the stemness of colorectal cancer cells. World J Stem Cells 2023; 15(5): 281-301
URL: https://www.wjgnet.com/1948-0210/full/v15/i5/281.htm
DOI: https://dx.doi.org/10.4252/wjsc.v15.i5.281