Bone marrow mesenchymal stem cell-derived exosomal microRNAs target PI3K/Akt signaling pathway to promote the activation of fibroblasts

Figure 9 Inhibition of phosphatase and tensin homolog change the gene expression of fibroblastic-, tenogenic-, and chondrogenic-related factors in NIH3T3 cells. The mRNA level of α-smooth muscle actin, vimentin, TNMD, Col I, Sox-9, and Col II in NIH3T3 cells treated with or without SF1670 was determined by quantitative real-time reverse transcription polymerase chain reaction. Data are shown as mean ± SD. ^aP < 0.05, ^bP < 0.01. α-SMA: α-smooth muscle actin.