Review
Copyright ©The Author(s) 2023.
World J Stem Cells. Apr 26, 2023; 15(4): 165-181
Published online Apr 26, 2023. doi: 10.4252/wjsc.v15.i4.165
Table 2 Extracellular vesicles investigated in clinical studies
Research title
Interventions
Status
Treatment of Patients with Bone Tissue Defects Using Mesenchymal Stem Cells Enriched by Extracellular VesiclesMSCs enriched by extracellular vesicles Not yet recruiting
Bone Marrow Mesenchymal Stem Cell Derived Extracellular Vesicles Infusion Treatment for ARDS Bone Marrow MSC Derived Extracellular Not yet recruiting
Efficacy of Platelet- and Extracellular Vesicle-rich Plasma in Chronic Postsurgical Temporal Bone Inflammations Plateletand extracellular vesicle-rich plasma Completed
Use of Autologous Plasma Rich in Platelets and Extracellular Vesicles in the Surgical Treatment of Chronic Middle Ear Infections Plateletand EVs-rich plasma Recruiting
Extracellular Vesicle Infusion Treatment for COVID-19 Associated ARDS ExoFlo Completed
Safety of Mesenchymal Stem Cell Extracellular Vesicles (BMMSC-EVs) for the Treatment of Burn Wounds Drug: AGLE-102 (BMMSC-EVs) Not yet recruiting
Treatment of Non-ischemic Cardiomyopathies by Intravenous ExtracellularVesicles of CardiovascularProgenitor CellsExtracellular vesicle-enriched secretome of cardiovascular progenitor cells differentiated from induced pluripotent stem cells Not yet recruiting
Bone Marrow Mesenchymal Stem Cell Derived Extracellular Vesicles Infusion Treatment for Mild-to-Moderate COVID-19: A Phase II Clinical Trial Drug: ExoFlo. Bone Marrow Mesenchymal Stem Cell Derived Extracellular VesiclesNot yet recruiting
A Safety Study of IV Stem Cellderived Extracellular Vesicles (UNEX-42) in Preterm Neonates at High Risk for BPD UNEX-42 is a preparation of extracellular vesicles that are secreted from human bone marrow-derived mesenchymal stem cells suspended in phosphate-buffered salineTerminated
ExoFlo™ Infusion for Post-Acute COVID-19 and Chronic Post COVID-19 Syndrome Bone Marrow Mesenchymal Stem Cell Derived Extracellular Vesicles Not yet recruiting
Study of ExoFlo for the Treatment of Medically Refractory Ulcerative Colitis ExoFlo. Intravenous administration of bone marrow mesenchymal stem cell derived extracellular vesiclesRecruiting
Study of ExoFlo for the Treatment of Medically Refractory Crohn's DiseaseExoFlo. Intravenous administration of bone marrow mesenchymal stem cell derived extracellular vesiclesRecruiting
Bone Marrow Mesenchymal Stem Cell Derived EVs for COVID-19 Moderate-to-Severe ARDS: A Phase III Clinical Trial EXOFLO. Bone Marrow Mesenchymal Stem Cell Derived EVsRecruiting
Pilot Study of Human Adipose Tissue Derived Exosomes Promoting Wound Healing Adipose tissue derived exosomes Not yet recruiting
Exosome Effect on Prevention of Hairloss Placental Mesenchymal Stem Cells-derived ExosomeRecruiting
Expanded Access for Use of ExoFlo in Abdominal Solid Organ Transplant Patients Bone Marrow Mesenchymal Stem Cell Derived Extracellular Vesicles Infusion Treatment Not yet recruiting
Safety of Injection of Placental Mesenchymal Stem Cell Derived Exosomes for Treatment of Resistant Perianal Fistula in Crohn's PatientsPlacenal MSC derived exosomesActive, not recruiting
Safety and Efficacy of Injection of Human Placenta Mesenchymal Stem Cells Derived Exosomes for Treatment of Complex Anal Fistula Placenta MSCs derived exosomes Recruiting
Safety and Tolerability Study of MSC Exosome Ointment Exosome ointment Completed
The Pilot Experimental Study of the Neuroprotective Effects of Exosomes in Extremely Low Birth Weight Infants Exosomes derived from MSCsNot yet recruiting